A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis.
نویسندگان
چکیده
We conducted a trial of oral acetazolamide for the treatment of cryptococcal meningitis in 22 Thai adults with headache and an opening cerebrospinal fluid pressure of >/=200 mm H(2)0. The trial was terminated prematurely because patients who received acetazolamide developed significantly lower venous bicarbonate levels and higher chloride levels and had more-frequent serious adverse events than did subjects who received placebo.
منابع مشابه
Acetazolamide therapy and intracranial pressure.
The role of " colonization pressure " in the spread of vancomycin-resistant enterococci: an important infection control variable. Sir—We read with interest the article entitled " A Randomized, Double-Blind, Placebo Controlled Trial of Acetazolamide for the Treatment of Elevated Intracranial Pressure in Cryptococcal Meningitis " by Newton et al. [1], which evaluated the addition of acetazolamide...
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ورودعنوان ژورنال:
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
دوره 35 6 شماره
صفحات -
تاریخ انتشار 2002